The first order of business when sterile filtering an aqueous, oil or medication is to select a filter that is chemically compatible to the solution. A great technique with excellent procedures and a state of the art facility will yield a fail result if the filter materials aren’t chemically compatible with the filtered solution or medication. Usually the membrane or seal between the membrane and filter shell are compromised when the filter materials aren’t chemically compatible with the filter solution. This yields a non-sterile product and a low bubble point when integrity testing the filter after use.

Unfortunately, the table below isn’t a comprehensive list for all solutions that sterile compounding pharmacies use; however, it should serve as a valuable guide. We are continually revising the list. If information is needed regarding a compound or solution not found on the list below, we will try to assist by using our vast network, chemical compatibility charts for plastics used in filters or, as a last result, we can supply filters with different materials until we arrive at the correct solution.

Chemical PTFE PP PES Nylon PVDF HDPE Recommendation
Ascorbic Acid “A” “A” “A” PES/PP
Benzal Chloride “A” “A/B” @10% Sol’n No Data "A" "A" "A" PTFE/PP, All Nylon
Benzal Conium Chloride “A” “A/B” @10% Sol’n No Data "A" "A" "A" PTFE/PP, All Nylon
Benzyl Alcohol “A” “A” “A” PES/PP
Benzyl Benzoate “A” “A” “A” Low Conc. PTFE/PP
Caprylic/Capric Triglyceride “A” PTFE/PP
Chlorobutanol up to 2% “A” “A” “A” PES/PP or PTFE/PP
Corn Oil “A” “A” “A” PES/PP
Cottonseed Oil “A” “A” “A” PES/PP
Cyclosprorine “A” “A” “A” PES/PP
Cyclosprorine Ophthalmic Sol’n “A” “A” “NR” PTFE/PP
Dextrose “A” “A” “A” PES/PP
Dimethylacetamide Low Concentration “A” “A” “A”
Ethanol Alcohol / Ethyl Alcohol “A” “A” “A” PES/PP, PTFE/PP
Formaldehyde “A” “A” “A” @ 40% Sol’n “A” @ 37% Sol’n "A" "A" PES/PP, PTFE/PP or PVDF/HDPE
Glycerol “A” “A” “A” "A" "A" "A" PES/PP
Glycol “A” “A” “A” PES/PP
Grape Seed “A” “A” “A” PES/PP
Guaifenesin “A” “A” “A” PES/PP
Iodine “A” “A” No Data "NR" "A/B" "NR" PTFE/PP or PES/PP
Linseed Oil “A” “A” “A” "A" "A" "NR" PES/PP
Peanut Oil “A” “A” “A” PES/PP
Propylparaben up to 2% “A” “A” "A" PTFE/PP or PES/PP
NaOH “A” “A” "A" PTFE/PP or PES/PP
Phenol “A” “A” No Data "NR" "A" "A" PTFE/PP , PVDF/PP or PES / PP
Progesterone “A” “A” PTFE/PP
Sesame Oil “A” “A” to 70 °F No Data “A” to 70 °F PTFE/PP or Nylon/PP
Sodium Hydroxide “A” - 70 to 100%, 180 °F “A” Low Conc. “A” - 80 to 100%, 140 °F
Testosterone "A" “A” PES/PP

PTFE – Teflon
PP – Polypropylene
PES- Polyethersulfone
HDPE – High density polyethylene
“A” – Excellent compatibility
“A/B” – Good Compatibility
“NR” – Not Recommended

Reference Source: Compass Publications, Chemical Resistance Guide for Plastics

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