The first order of business when sterile filtering an aqueous, oil or medication is to select a filter that is chemically compatible to the solution. A great technique with excellent procedures and a state of the art facility will yield a fail result if the filter materials aren’t chemically compatible with the filtered solution or medication. Usually the membrane or seal between the membrane and filter shell are compromised when the filter materials aren’t chemically compatible with the filter solution. This yields a non-sterile product and a low bubble point when integrity testing the filter after use.
Unfortunately, the table below isn’t a comprehensive list for all solutions that sterile compounding pharmacies use; however, it should serve as a valuable guide. We are continually revising the list. If information is needed regarding a compound or solution not found on the list below, we will try to assist by using our vast network, chemical compatibility charts for plastics used in filters or, as a last result, we can supply filters with different materials until we arrive at the correct solution.
PTFE – Teflon
PP – Polypropylene
HDPE – High density polyethylene
“A” – Excellent compatibility
“A/B” – Good Compatibility
“NR” – Not Recommended
Reference Source: Compass Publications, Chemical Resistance Guide for Plastics