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Biological Grade CRT-PES Series PES Membrane Filter Cartridge [Absolute]
The CRT-PES Series Biological Grade Filter Cartridges are IFP’s most advanced biological-grade solution, designed for high-end biopharmaceutical filtration where reliability and sterility are critical. Built with a hydrophilic PES (polyethersulfone) membrane, these cartridges provide absolute-rated retention validated by microbial challenge testing, making them the gold standard for serum and protein-based processing.
Their low protein-binding properties ensure maximum recovery of sensitive biomolecules, while broad pH compatibility (1–14) supports demanding multistage filtration setups. Pre-rinsed with pyrogen-free water, CRT-PES cartridges eliminate pre-wetting steps, reduce contamination risks, and integrate seamlessly into blood serum clarification, intermediate polishing, and biological-grade filtration.
Relevant Industries
• Biopharmaceutical Manufacturing
• Biotechnology
• Pharmaceutical Prefiltration
• Buffers and Media Filtration
• Blood Serum Filtration
• Large Volume Parenteral (LVPs)
• Vaccines and Biologics
• Fermentation Broth Clarification
• Final Sterilizing Filtration
• Scale-Up and Clinical Batches
• Antibiotics and Protein-Based Pharmaceuticals
• Micron Ratings:
0.10 µm, 0.20 µm, 0.45 µm, 0.65 µm, 0.80 µm, 1.2 µm
• Effective Filtration Area:
1. 10-Inch: 0.7 m²
2. 20-Inch: 1.4 m²
3. 30-Inch: 2.1 m²
• Materials of Construction:
1. Filter Media: PES - Biological Grade (Hydrophilic, Low Protein Binding, High Flow Rate)
2. Supports, Core, Cage, End Caps: Polypropylene
3. O-Rings: Silicone (Standard), EPDM, Viton, or Teflon-encapsulated options
4. Sealing: Thermally bonded, adhesive-free
• Operating Conditions:
1. Max Forward Differential Pressure: 5.5 bar (80 psi) at 25°C
2. Max Operating Temp: 80°C (176°F) at 0.7 bar
3. Min Burst Pressure: 8.3 bar (120 psi)
4. Max Reverse Pressure: 3.0 bar (44 psi)
• Bacterial Retention:
1. 0.1 µm: LRV ≥ 8 (B. diminuta)
2. 0.2 µm: LRV ≥ 7 (B. diminuta)
3. 0.45 µm: LRV ≥ 7 (S. marcescens)
4. 0.65 µm: LRV ≥ 7 (L. brevis)
5. 0.8 µm: LRV ≥ 7 (S. cerevisiae)
• Physicochemical Testing:
1. USP Oxidizable Substances
2. USP <645> Conductivity
3. USP <643> TOC / Non-Volatile Residue
• Cleanliness:
1. USP <85> Bacterial Endotoxin Test
2. USP <788> Particulate Matter
• Biocompatibility:
1. USP <88> Biological Reactivity (Class VI Plastics)
2. USP <87> Cytotoxicity
3. ASTM F756-17 Hemolysis
• Sterilization Compatibility:
1. Autoclave: Up to 50 cycles at 125°C for 30 min
2. Steam-in-Place (SIP): Up to 30 cycles at 135°C for 30 min
3. Hot water or chemical sanitization options available
• Traceability:
1. Certificate of Conformance with each cartridge
2. Laser-engraved part number and lot number on each filter
3. Fully labeled bag and box for supply chain traceability
• Shelf Life:
1. 3 years from the date of manufacture
Fit of IFP CRT Cartridges with Filter Housings
The choice of cartridge end cap significantly impacts sealing performance, pressure rating, and fluid distribution. The 226 O-Ring Fin (Code 7) is the most secure and widely used in critical applications, while DOE (Code 0) remains an older technology; its use is limited mainly to non-sterile processes.
End Cap Type | Housing Connection | Details |
226 O-Ring Fin (Code 7) Most Popular - Highest Pressure Rating | Recessed 226 O-ring groove with locking tabs and center receptor for fin | Offers the most secure fit with dual O-ring compression and bayonet locking tabs. The integrated fin aligns the cartridge, enhancing pressure stability and promoting even solution distribution. |
222 O-Ring Flat (Code 2) | Recessed 222 O-ring groove with flat bottom | The housing head features a precision-machined cavity to fit the 222 O-ring, ensuring tight axial compression. Uses a flat receptacle-no locking tabs. |
226 O-Ring Flat (Code 6) | Recessed 226 O-ring groove with flat bottom | Features a wider, deeper groove for 226 O-rings. Provides enhanced sealing over 222 but lacks bayonet lock or fin alignment. |
Flat Gasket (Code 0) Least Popular - Lowest Pressure Rating | Flat knife-edge or gasket seat at both ends | Cartridge is held by compression plates or spring caps. No O-rings or locking tabs-best for low-pressure, general-purpose filtration. |
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